• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia

Trendingnow

1

Philanthropy leader at Warren Buffett and Bill Gates’ Giving Pledge says children of billionaires are pushing them to give their wealth away faster

2

MacKenzie Scott alone accounted for one-third of America's $19.2 billion in megagifts last year

3

The 33-year-old executive Satya Nadella is trusting to fix Microsoft’s Copilot AI assistant

1

Philanthropy leader at Warren Buffett and Bill Gates’ Giving Pledge says children of billionaires are pushing them to give their wealth away faster

2

MacKenzie Scott alone accounted for one-third of America's $19.2 billion in megagifts last year

3

The 33-year-old executive Satya Nadella is trusting to fix Microsoft’s Copilot AI assistant
HealthCoronavirus

The 5 types of long COVID, according to one health expert

By
Erin Prater
Erin Prater
Down Arrow Button Icon
By
Erin Prater
Erin Prater
Down Arrow Button Icon
May 31, 2022, 5:00 AM ET
Add Fortune on Google for similar content.

Between 7 million and 23 million Americans are estimated to have long COVID, according to a recent report by the U.S. Government Accountability Office.

With more than 200 symptoms identified so far, ranging from a lingering cough, fatigue, peeling skin, hallucinations, and a sensation some patients describe as “brain on fire,” they can’t all have the same thing, right?

Experts are starting to ask that question, too.

As researchers race to understand just what long COVID is, an increasing number are attempting to divide the new, potentially debilitating disease into groups.

Dr. Alexandra Brugler Yonts, an infectious disease specialist at Children’s National Hospital in Washington, D.C., and the head of its new Pediatric Post-COVID Program, told Fortune she divides the types of long COVID into five categories, grouped by causes.

1. Long-term direct effects

COVID damaged the organs of these patients during the course of disease, causing long-term health repercussions. A recent study published in the journal Radiology found that roughly half of the nearly 100 COVID patients examined had persistent lung damage a year after infection.

2. Inflammation

During infection, the virus triggered the body’s release of inflammasomes, which kill infected cells. But the fallout can wreak havoc in various organ systems, especially if the process persists after infection.

3. Dysautonomia

In dysautonomia, patients experienced direct damage to the autonomic nervous system that persists after infection. One type of dysautonomia thought to afflict long-COVID sufferers is postural orthostatic tachycardia syndrome, or POTS. Potentially autoimmune in nature, the syndrome causes disruptions in heart rate and blood pressure in response to changes in position.

4. Ongoing viral activity

In these patients, COVID isn’t quite ready to give up yet. Ongoing viral activity could be caused by “ghost” virus cells that can linger for months after initial infection. Recent research has found that such cells, when located in the gut, can cause ongoing gastrointestinal symptoms, like diarrhea, that aren’t typical of a respiratory virus.

5. Altered immune response

This can be seen alone or in combination with the other categories, Yonts said. In order to bring itself back to normal during COVID infection, the immune system overcorrects, resulting in extended susceptibility to a number of viruses the body might usually fight off. Anecdotally, she’s heard of patients in their twenties who had COVID and then came down with a slew of other illnesses in short order, like mono and strep.

Know thine enemy

When it comes to COVID long haulers, there are clearly “different pathologies at play,” Yonts said. “I don’t think there’s one process that is ‘long COVID’ in every single person. There are multiple processes going on.”

The sooner researchers can nail down the causes, the sooner they can develop targeted treatments, she said. Currently, symptoms are treated, and patients many undergo therapies to regain lost abilities—but not much more can be done.

“Once we can more solidly tease that out, it will lead to better ways to manage those patients and more focused pharmaceutical treatments,” Yonts said.

Sign up for the Fortune Features email list so you don’t miss our biggest features, exclusive interviews, and investigations.

About the Author
By Erin Prater
See full bioRight Arrow Button Icon
Add Fortune on Google for similar content.

Latest in Health

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • World's Most Admired Companies
  • See All Rankings
  • Lists Calendar
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
  • Group Subscriptions
About Us
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Latest in Health

France suffers 1,000 additional deaths in just the past week amid record heat wave—and 85% involved people aged 65 and above
EuropeWeather and forecasting
France suffers 1,000 additional deaths in just the past week amid record heat wave—and 85% involved people aged 65 and above
By Kirsten Grieshaber, John Leicester and The Associated PressJune 28, 2026
4 hours ago
Peter Rahal speaks on stage in front of a black and purple background.
RetailFood and drink
David Protein CEO says ‘diet trends are over’ because of GLP-1s: ‘What’s next is really hard to predict’
By Sasha RogelbergJune 28, 2026
6 hours ago
What 3 million Americans quitting Obamacare shows: Republicans couldn’t repeal it, so they made it unaffordable
HealthHealth Insurance
What 3 million Americans quitting Obamacare shows: Republicans couldn’t repeal it, so they made it unaffordable
By Ali Swenson and The Associated PressJune 27, 2026
21 hours ago
g
EuropeGermany
It’s so hot in Germany the Autobahn literally burst open at the seams and had to be closed down
By Kirsten Grieshaber, Sylvia Hui, John Leicester and The Associated PressJune 27, 2026
1 day ago
Best Beef Organ Supplements (2026): Expert Tested and Reviewed
HealthDietary Supplements
Best Beef Organ Supplements (2026): Expert Tested and Reviewed
By Emily PharesJune 26, 2026
2 days ago
Yes, Europe’s heat waves are deadlier than American gun violence
EnvironmentEurope
Yes, Europe’s heat waves are deadlier than American gun violence
By Catherina GioinoJune 26, 2026
2 days ago

Most Popular

Philanthropy leader at Warren Buffett and Bill Gates’ Giving Pledge says children of billionaires are pushing them to give their wealth away faster
Success
Philanthropy leader at Warren Buffett and Bill Gates’ Giving Pledge says children of billionaires are pushing them to give their wealth away faster
By Preston ForeJune 27, 2026
1 day ago
MacKenzie Scott alone accounted for one-third of America's $19.2 billion in megagifts last year
Success
MacKenzie Scott alone accounted for one-third of America's $19.2 billion in megagifts last year
By Sydney LakeJune 25, 2026
3 days ago
The 33-year-old executive Satya Nadella is trusting to fix Microsoft’s Copilot AI assistant
AI
The 33-year-old executive Satya Nadella is trusting to fix Microsoft’s Copilot AI assistant
By Sebastian HerreraJune 27, 2026
1 day ago
The end of Putin’s regime will spring from war spending chaos, former central bank advisor says, amid military mutiny threat and fuel-shortage brawls
Europe
The end of Putin’s regime will spring from war spending chaos, former central bank advisor says, amid military mutiny threat and fuel-shortage brawls
By Jason MaJune 27, 2026
23 hours ago
Now worth $200 million, Sarah Jessica Parker credits being ‘one of eight kids that struggled financially’ for her hunger, ambition, and work ethic
Success
Now worth $200 million, Sarah Jessica Parker credits being ‘one of eight kids that struggled financially’ for her hunger, ambition, and work ethic
By Orianna Rosa RoyleJune 24, 2026
4 days ago
Ex-Google engineer says Larry Page, Sergey Brin and Sundar Pichai share the same trait—it's the lesson he swears by as a $7.2 billion AI CEO
Success
Ex-Google engineer says Larry Page, Sergey Brin and Sundar Pichai share the same trait—it's the lesson he swears by as a $7.2 billion AI CEO
By Orianna Rosa RoyleJune 28, 2026
7 hours ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.