We tested six berberine supplements, considering aspects such as swallowability, taste, side effects, value, and more. Read on for our top five picks and to learn more about berberine.

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Best Berberine Supplements of 2026

• Best Berberine Supplement Overall: PartiQlar Pure Berberine HCL
• Best High-Dose Berberine Supplement: Legion Berberine
• Best Extended-Release Berberine Supplement: MidiHealth Berberine+
• Best Value Berberine Supplement: ProHealth Berberine Pro
• Best Berberine Supplement for Absorption: Rho Nutrition Liposomal Berberine

Best Berberine Supplements Comparison Table

Berberine Supplements	Berberine Per Serving	Form	Serving Size	Additional Ingredients
PartiQlar Pure Berberine HCL	600 mg	Vegetable cellulose capsules	1 capsule	N/A
Legion Berberine	1500 mg	Veggie capsules	3 capsules	White rice flour, bamboo extract
MidiHealth Berberine+	250 mg Dihydroberberine (DHB)	Vegetable hypromellose capsules	2 capsules	N/A
ProHealth Berberine Pro	600 mg	Vegetable hypromellose capsules	1 capsule	BioPerine Black Pepper Fruit Extract
Rho Nutrition Liposomal Berberine	300 mg	Vegetable cellulose capsules	1 capsule	N/A

PartiQlar Pure Berberine HCL
Berberine Per Serving	600 mg
Form	Vegetable cellulose capsules
Serving Size	1 capsule
Additional Ingredients	N/A
Legion Berberine
Berberine Per Serving	1500 mg
Form	Veggie capsules
Serving Size	3 capsules
Additional Ingredients	White rice flour, bamboo extract
MidiHealth Berberine+
Berberine Per Serving	250 mg Dihydroberberine (DHB)
Form	Vegetable hypromellose capsules
Serving Size	2 capsules
Additional Ingredients	N/A
ProHealth Berberine Pro
Berberine Per Serving	600 mg
Form	Vegetable hypromellose capsules
Serving Size	1 capsule
Additional Ingredients	BioPerine Black Pepper Fruit Extract
Rho Nutrition Liposomal Berberine
Berberine Per Serving	300 mg
Form	Vegetable cellulose capsules
Serving Size	1 capsule
Additional Ingredients	N/A

Best Berberine Supplement: PartiQlar Pure Berberine HCL

Our Thoughts on PartiQlar Pure Berberine HCL

PartiQlar Pure Berberine HCL is our pick for the best overall berberine supplement because it’s in a more absorbable form than berberine alone: it’s 600 milligrams of berberine hydrochloride per serving, which is typically more easily absorbed by the body and has been studied more than berberine on its own. 

Courtney tested PartiQlar Pure Berberine HCL, rating her first impression of the product a 5 out of 5. “The packaging has a clean, minimal, and premium look that fits well with a health and wellness supplement,” she said. “The container is well-designed without being bulky, making it easy to store at home or take along with you when traveling. Overall, the packaging feels practical and user-friendly, especially for someone who prefers supplements that are easy to add into a daily routine without extra steps,” Courtney said.

Our tester rated the swallowability of PartiQlar Pure Berberine HCL a 5 out of 5, as well. “The serving size is reasonable and doesn’t require taking a large handful of pills at once,” she said. “Taking my berberine is easy to remember and fits naturally into my daily supplement routine. The capsule size and serving amount make this product feel practical for consistent use.”

Courtney rated this berberine supplement’s taste a 3 out of 5. “The capsules taste neutral; I didn’t notice any sweetness, chalkiness, or sugary coating on the capsules. There’s no strong bitterness or lingering aftertaste, either.”

Of her overall experience, Courtney liked that it was a low-maintenance supplement that fit in well with her lifestyle. “It didn’t feel like an extra chore to keep up with, which is important for something I’m taking regularly. I found the experience convenient and appreciate the simple capsule format and ease of use.”

Focusing strictly on weight loss? Check out our full review of the Noom app.

Specs:

• Berberine dosage: 600 mg
• Serving size: 1 capsule
• Servings per container: 60
• Other vitamins and minerals: N/A

Best High-Dose Berberine Supplement: Legion Berberine

Our Thoughts on Legion Berberine

Legion Berberine is our pick for the best high-dose berberine supplement because it contains 1,500 milligrams of berberine HCL per serving, which is three capsules total. Berberine studies have frequently tested this dose. A 2022 review of 49 studies on berberine for cardiovascular improvement (lowered cholesterol, reduced resistance to insulin, and more) noted that at least 1,000 milligrams (one gram) of berberine was optimal for weight loss and more could be taken to improve other cardiovascular outcomes. We recommend talking with your doctor before starting any supplement, including berberine.

Pete tested Legion’s Berberine, rating his first impression a 5 out of 5. “It comes in a black plastic bottle with a screw-top lid that opens and closes easily. It’s travel-friendly, about two and a half inches wide and four inches tall, and would easily fit into a purse, backpack, or gym bag,” he said. “The label is well-designed, and the front of the label features some benefits/facts about the product, including ‘supports metabolic health, clinically effective ingredient and dose, and third-party lab tested for purity.’”

He rated swallowability a 3 out of 5. “This berberine comes in a capsule form; the powder inside is yellow. It’s about three-quarters of an inch in length and half a centimeter in diameter. The recommended serving size is three capsules per day taken with food,” Pete said. 

Our tester rated the taste a 3 out of 5. “The capsules are tasteless,” he said. “I took it for one day and took one capsule with each meal. That said, I do know that some people have issues with berberine supplements. I’ve heard of side effects like stomach cramping, nausea, and diarrhea. It seems like this supplement is pretty hard on the gut. The reason I don’t think I had any issues is that the directions suggest splitting the doses up throughout the day with food. Taking this all in one sitting would probably cause these effects.”

Of her overall experience, Pete said, “I like that this product is third-party tested for purity. People sometimes refer to berberine as ‘nature’s Ozempic,’ and it does have some blood sugar control benefits, like improving insulin sensitivity. This has caused people to use it as a weight management tool, and it may cause some modest weight loss effects,” he said. 

Specs:

• Berberine dosage: 1,500 mg
• Serving size: 3 capsules
• Servings per container: 30
• Other vitamins and minerals: N/A

Best Extended-Release Berberine Supplement: MidiHealth Berberine+

Our Thoughts on MidiHealth Berberine+

MidiHealth Berberine is our pick for the best extended-release berberine supplement because it includes 250 milligrams of dihydroberberine per serving and is housed in a slow-release capsule. MidiHealth is a brand that carries supplements made for women in various stages of midlife, and the brand also offers virtual health visits.

Courtney tested MidiHealth’s Berberine+, rating it a 5 out of 5 for her first impression. “I liked the bright orange and pink label,” she said. “The label is easy to read and highlights the features of the product. The bottle is a similar size to other dietary supplements and would be easy to take on the go. The bottle is easy to open; there are no safety features.”

She rated the swallowability of Berberine+ as a 5 out of 5 as well. “The pills are typical gel capsules; a single serving is two pills. I found the pills extremely easy to swallow, and there was no aftertaste,” Courtney mentioned.

Overall, Courtney has had a positive experience. “I generally feel normal and haven’t noticed any negative side effects or discomfort. One thing I was concerned about before trying it was the potential for digestive issues, but I haven’t experienced any stomach upset, bloating, or nausea,” she said. “While I haven’t been using it long enough to comment on major long-term effects, I appreciate how easy it is to take and how well I’ve tolerated it. Overall, it’s been a simple, hassle-free supplement that fits well into my wellness routine without causing any issues.”

Looking for the best multivitamin to take along with Berberine+? Check out our picks for the best multivitamins for women.

Specs:

• Berberine dosage: 250 mg dihydroberberine (DHB)
• Serving size: 2 capsules
• Servings per container: 30 
• Other vitamins and minerals: N/A

Best Value Berberine Supplement: ProHealth Berberine Pro

Our Thoughts on ProHealth Berberine Pro

ProHealth Berberine Pro is our pick for the best value berberine supplement because it costs just $29.95 for a one-time purchase as of this writing, which comes to 50 cents per one-capsule serving. The brand does recommend taking one capsule two to three times a day, so depending on how you tolerate this berberine, you may go through a bottle in less than 30 days. We also like that the subscribe and save discount is 30% off.

Paige tested ProHealth Berberine Pro, rating her first impression a 5 out of 5. “I really like the packaging; it has a frosted plastic and a smooth cap. The color scheme is also pleasant to look at,” she said. “The bottle is small, so it’d be very easy to travel with. There’s no child lock on the bottle.”

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Our tester rated the swallowability of this berberine a 1 out of 5. “The pill is a large capsule. You’re supposed to take one pill at a time, two to three times per day with food, which is a higher frequency than most supplements and may be hard to keep up with or coordinate along with food,” she said.

“The pill has a strange smell to it but no weird taste,” Paige said. “The powder inside the pill is neon yellow and transfers to the outside of the capsule, so I got yellow powder on my hands while taking this supplement. This would bother me if I had to get yellow on my hands three times a day. There was no poor aftertaste.” She rated the taste itself a 3 out of 5.

Of her overall experience, Paige thinks this berberine would be “a good supplement to take long term for those who are interested in more holistic options for anti-aging.” Additionally, she thinks that the frequency of taking the pills might be difficult for some folks to keep up with. “I also think that the yellow powder might bother some people because it could possibly transfer to clothes or other objects.”

Specs:

• Berberine dosage: 600 mg
• Serving size: One capsule
• Servings per container: 60
• Other vitamins and minerals: Chromium and black pepper extract

Best Berberine Supplement for Absorption: Rho Nutrition Liposomal Berberine

Our Thoughts on Rho Nutrition Liposomal Berberine

Rho Nutrition Liposomal Berberine is our pick for the best berberine supplement for absorption. This is the only berberine on our list that’s specially encased to ensure it is absorbed better by your body after digestion. The supplement is in phosphatidylcholine-based liposomes.

Courtney tested Rho Nutrition Liposomal Berberine, rating her first impression a 5 out of 5. “The container is comparable to other dietary supplement containers. I would not consider this overly bulky or larger than others. It can be taken on the go easily. The bottle is easy to open and does not have any safety features to make opening difficult,” she said. 

Our tester rated swallowability a 3 out of 5. “Due to the gel capsule texture, the pill is easy to swallow. If left in the mouth too long, the taste is bitter and unpleasant. Only one capsule is taken a day, which makes it easier compared to other products that require two or more daily,” Courtney said. She rated the taste of Rho’s berberine a 3 out of 5.

Of her overall experience, Courtney said she’s had a positive experience with Rho Liposomal Berberine so far. “The capsules are easy to take, and I haven’t experienced any digestive issues, stomach discomfort, or nausea while using the supplement.”

“While it’s too early for me to speak to significant long-term results, I value the quality of the ingredients and the liposomal formulation. My only potential concern is the cost compared to standard berberine supplements, but the enhanced delivery system may justify the premium for those looking for a more advanced option. Overall, it’s been a hassle-free addition to my wellness routine,” Courtney concluded.

Specs:

• Berberine dosage: 300 mg
• Serving size: One capsule
• Servings per container: 60
• Other vitamins and minerals: N/A, though it does include the brand’s Liposome Technology Lipid Blend

How Do Berberine Supplements Work?

“Berberine seems to work less like an appetite suppressant and more like a metabolic support compound. It may help the body handle glucose and fats more efficiently,” says Johannah Katz, RD. “One of the main pathways researchers talk about is AMPK, which is sometimes described as a cellular ‘energy sensor.’ When AMPK is activated, the body may improve glucose uptake, reduce glucose production in the liver, and support fatty acid use, which is why berberine has been studied for blood sugar, insulin resistance, cholesterol, triglycerides, and fatty liver-related conditions.”

She continues, “This is why berberine is sometimes compared to Metformin, because Metformin also affects metabolic pathways. Berberine is not the same as Metformin, though, and it should not be treated as a replacement for prescribed medication. Metformin is an FDA-approved medication with extensive clinical outcome and safety data, while berberine is a dietary supplement with variable formulations, lower bioavailability, and less consistent research quality.”

“Berberine may help shift the body toward better glucose and lipid metabolism, but it is not a magic weight-loss supplement and not a substitute for medical treatment and/or intervention,” Katz advises.

Types of Berberine Supplements

• Berberine HCl: This is a very commonly studied type of berberine
• Dihydroberberine (DHB): This is a more bioavailable type of berberine that may have fewer gastrointestinal side effects
• Liposomal berberine: This is when berberine is in liposomal or micellar form to enhance absorption

Why Berberine Supplements Matter to Professionals 

Evidence on what berberine can do is still limited; though berberine may lead to modest body weight, BMI, and waist circumference, especially when used for more than 8 weeks and at doses above 1 gram per day. The evidence is not conclusive, and many studies have limitations.

Berberine may be helpful for professionals who are aiming to improve metabolic factors and focus on longevity. 

How We Tested and Selected the Best Berberine Supplement

We tested and selected the best berberine supplements by evaluating swallowability, taste, third-party testing, certifications, value, and more. Here’s more about our testing.

Swallowability 

When testing berberine, we considered the taste of the capsules (if any). Our testers also report on ease of swallowing the supplements, number of capsules to swallow, and other details such as any bitterness or aftertaste.

Third-Party Testing

Our team places a strong emphasis on products that undergo third-party testing. This typically means an independent lab has verified that what’s on the label matches what’s in the container and has checked for certain contaminants. We check for up-to-date lab data on the product page, such as a recent certificate of analysis. Our team also considers whether the product has certifications, such as NSF Certified for Sport or Informed Choice.

Value

We weigh all factors against the cost per serving rather than just looking for the cheapest option.

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Berberine Supplements	Berberine Per Serving	Cost Per Serving	Cost Per Bottle
PartiQlar Pure Berberine HCL	600 mg	66 cents	$39.99
Legion Berberine	1,500 mg	$1.32	$39.99
MidiHealth Berberine+	250 mg Dihydroberberine (DHB)	$1.83	$54.99
ProHealth Berberine Pro	600 mg	50 cents	$29.95
Rho Nutrition Liposomal Berberine	300 mg	80 cents	$47.95

PartiQlar Pure Berberine HCL
Berberine Per Serving	600 mg
Cost Per Serving	66 cents
Cost Per Bottle	$39.99
Legion Berberine
Berberine Per Serving	1,500 mg
Cost Per Serving	$1.32
Cost Per Bottle	$39.99
MidiHealth Berberine+
Berberine Per Serving	250 mg Dihydroberberine (DHB)
Cost Per Serving	$1.83
Cost Per Bottle	$54.99
ProHealth Berberine Pro
Berberine Per Serving	600 mg
Cost Per Serving	50 cents
Cost Per Bottle	$29.95
Rho Nutrition Liposomal Berberine
Berberine Per Serving	300 mg
Cost Per Serving	80 cents
Cost Per Bottle	$47.95

Benefits of Berberine Supplements

Here are some possible benefits of berberine supplements, as discussed with Katz.

“Outside of weight loss, berberine has been studied most for cardiometabolic health, including blood sugar control, insulin resistance, cholesterol, triglycerides, inflammatory markers, and fatty liver-related outcomes. A 2022 systematic review and meta-analysis of 37 studies in people with type 2 diabetes found that berberine reduced fasting blood glucose, HbA1c, and 2-hour post-meal glucose, suggesting a glucose-lowering effect,” she said.

“Berberine has also been studied for lipid support. A 2025 systematic review and meta-analysis in metabolic syndrome found that berberine significantly improved several metabolic syndrome aspects, including triglycerides, fasting plasma glucose, and waist circumference, but the authors still called for more high-quality randomized controlled trials,” Katz said.

“While berberine may improve glucose, LDL cholesterol, triglycerides, insulin resistance,

inflammation, and liver enzymes. That is different from proving it prevents heart attacks, strokes, diabetes complications, or liver disease progression,” says Katz. 

“A 2025 review also notes promising effects for diabetes, NAFLD, lipid metabolism, inflammation, and cardiovascular risk pathways, but highlights limitations like low bioavailability and trial heterogeneity,” says Katz. “The NCCIH similarly notes that berberine is being studied for diabetes and heart disease risk factors, but the evidence is not definitive.”

“My evidence-based takeaway is that berberine is more reasonably described as a possible adjunct for cardiometabolic markers, not a replacement for medications, diet, exercise, or medical care. Anyone taking medication for blood sugar, blood pressure, cholesterol, blood thinning, or immunosuppression should discuss it with their medical provider first because berberine can interact with medications,” states Katz.

Potential Side Effects of Taking Berberine Supplements

Side effects of taking berberine may include gastrointestinal issues such as nausea, diarrhea, bloating, constipation, and more. While it may be well-tolerated in general, it’s good to look out for these side effects and talk with your doctor before starting a berberine supplement.

What to Avoid in Berberine Supplements

We recommend avoiding berberine supplements that have not been third-party tested, include proprietary blends or incredibly high doses, or promise quick overnight results.

“Berberine is not appropriate for everyone,” says Katz. “I would avoid berberine during pregnancy or breastfeeding, and it should not be given to infants. I would also be cautious with berberine in anyone taking medications for diabetes, blood pressure, blood thinning, or immunosuppression, because berberine may interact with several medications and could increase the risk of side effects or low blood sugar depending on the situation.”

“People with chronic medical conditions, liver or kidney concerns, or anyone taking multiple medications should speak with their medical provider before using berberine,” says Katz.

How to Find the Best Berberine Supplement for You

The best berberine for you will depend on your health goals and budget. Here are some aspects to consider when shopping for the best berberine supplement for you.

Your Wellness Goals

Berberine has been studied for its effects on glucose regulation, insulin sensitivity, inflammation, and more, which may be relevant for people who’ve experienced metabolic syndrome, insulin resistance, prediabetes, type 2 diabetes, PMOS, and more. Depending on your health goals, we recommend talking with your doctor to see if berberine may benefit you. 

“I would describe berberine as potentially helpful for cardiometabolic support, with possible modest weight-related benefits, not as a guaranteed fat-loss supplement,” Katz said.

Form

Berberine is usually sold in capsule form and often in vegan or vegetarian varieties. Consider what will work best for your lifestyle before purchasing.

Cost

Before buying a berberine supplement, check the price per serving and how often you’ll be repurchasing it. Sometimes the subscribe-and-save discount can be very beneficial, and other times, it’s not worth it, especially if you’re not sure how long you want to use the berberine.

Fortune’s Final Thoughts

If you’re considering taking berberine for longevity, metabolic health, or other benefits, we recommend speaking with your doctor about possible interactions before starting. In general, berberine may offer modest results over time but is not a quick fix or a substitute for an overall healthy mindset: following a healthful way of eating, exercise, and quality sleep. Having realistic expectations and goals in mind is a great way to approach taking berberine.

Frequently asked questions

What cannot be mixed with berberine?

If you’re considering starting berberine, talk with your doctor about any medications and supplements you may be taking. More research is needed on berberine and its interactions.

What to look out for when buying berberine?

When buying berberine, check whether it is third-party tested and holds any certifications. If the product page has an up-to-date COA (certificate of analysis) listed, that’s even better.

Is there a downside to taking berberine?

Berberine may cause some gastrointestinal side effects like nausea, bloating, constipation, diarrhea, or abdominal discomfort.